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Food and Drug Administration (FDA) Endocrinologic and Metabolic Drugs Advisory Committee did not recommend approval of Zimulti (rimonabant) to the US FDA for use in obese and overweight patients with associated risks factors because of continuing concerns about increased risks for suicidal thoughts among some users. Acomplia (rimonabant) is the aboriginal in a new chic of ameliorative agents alleged Cannabinoid-1 Receptor Blockers (CB1). 25 percent increase in percent atheroma volume (PAV) in those taking rimonabant, compared to 0. 16 issue of the British Medical Journal, Padwal's team found that long-term users of weight-loss drugs such as orlistat (Xenical), sibutramine (Meridia) and rimonabant experienced only modest weight loss -- less than 11 pounds, which was less than 5 percent of their total body weight. Food and Drug Administration (FDA) Endocrinologic and Metabolic Drugs Advisory Committee did not recommend approval of rimonabant (Zimulti / Accomplia) to the US FDA. Rimonabant is not yet approved for use in the United States, where it is known as Zimulti.

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